Gambaran Ultrasonografi Hati pada Pasien Non-Alcoholic Fatty Liver Disease dengan Hipertensi
DOI:
https://doi.org/10.35790/msj.v8i1.59939Abstract
Abstract: Non-alcoholic fatty liver disease (NAFLD) has become a major global health concern with a rising prevalence worldwide. Hypertension and NAFLD have a bidirectional relationship, meaning that each can influence the other. Ultrasonography is the primary radiological method utilized to identify this liver condition. This study aimed to evaluate the liver ultrasonographic characteristics in patients diagnosed with NAFLD and hypertension at Prof. Dr. R. D. Kandou Hospital between September 2023 and August 2024. This was a descriptive and retrospective study with a cross-sectional design. Data were obtained from patient medical records through a total sampling method. The results identified 108 patients with NAFLD and hypertension, predominantly female patients (56.5%), aged 56-65 years (38.9%), and severity grade 1 or mild (64%). The distribution of severity levels based on gender and age groups was mostly found in grade 1 or mild severity in females (37%) and age group 56-65 years (25.9%). In conclusion, NAFLD patients with hypertension are predominantly female, aged 56-65 years, and have grade 1 severity (mild).
Keywords: non-alcoholic fatty liver disease; ultrasonography; hypertension
Abstrak: Non-alcoholic fatty liver disease (NAFLD) merupakan masalah kesehatan yang terjadi secara global dengan prevalensi yang terus meningkat Hipertensi dan NAFLD memiliki hubungan dua arah yang artinya masing-masing dapat saling memengaruhi. Ultrasonografi merupakan metode pemeriksaan radiologis yang paling sering digunakan untuk mendeteksi penyakit hati. Penelitian ini bertujuan untuk menggambarkan hasil ultrasonografi hati pada pasien dengan NAFLD yang disertai hipertensi di RSUP Prof. Dr. R. D. Kandou selama periode September 2023 hingga Agustus 2024. Jenis penelitian ialah deskriptif retrospektif dengan desain potong lintang. Data penelitian diperoleh dari rekam medis pasien menggunakan teknik total sampling. Hasil penelitian menunjukkan terdapat 108 pasien NAFLD dengan hipertensi, mayoritas berjenis kelamin perempuan (56,5%), dengan kelompok usia terbanyak berada pada rentang 56-65 tahun (38,9%), dan derajat keparahan 1 atau ringan (64%). Distribusi derajat keparahan berdasarkan jenin kelamin dan kelompok usia paling banyak pada derajat 1 atau ringan pada pasien perempuan (37%) dan usia 56-65 tahun (25,9%). Simpulan penelitian ini ialah pasien NAFLD dengan hipertensi sebagian besar berjenis kelamin perempuan, berusia 56-65 tahun, dan memiliki derajat keparahan ringan (derajat 1)
Kata kunci: non-alcoholic fatty liver disease; ultrasonografi; hipertensi
References
Mitra S, De A, Chowdhury A. Epidemiology of non-alcoholic and alcoholic fatty liver diseases. Transl Gastroenterol Hepatol. 2020;5:16. Doi:10.21037/tgh.2020.01.02.
Antunes C, Azadfard M, Hoilat GJ, Gupta M. Fatty Liver. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan [updated 2023 Jan 1]. Available from: https://www.ncbi.nlm.nih.gov/ books/NBK441992/
Powell EE, Wong VW, Rinella M. Non-alcoholic fatty liver disease. Lancet. 2021;397(10290):2212–24. Doi:10.1016/S0140-6736(20)32511-3
Younossi ZM, Golabi P, Paik JM, Henry A, Van Dongen C, Henry L. The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review. Hepatology. 2023;77(4):1335–47. Doi:10.1097/HEP.0000000000000004.
Wu W, Ma W, Yuan S, Feng A, Li L, Zheng H, et al. Associations of unhealthy lifestyle and nonalcoholic fatty liver disease with cardiovascular healthy outcomes. J Am Heart Assoc. 2023;12(23):e031440. Doi:10.1161/JAHA.123.031440.
Hardy T, Wonders K, Younes R, Aithal GP, Aller R, Allison M, et al. The European NAFLD Registry: A real-world longitudinal cohort study of nonalcoholic fatty liver disease. Contemp Clin Trials. 2020;98: 106175. Available from: https://doi.org/10.1016/j.cct.2020.106175
Kudaravalli P, John S. Nonalcoholic Fatty Liver. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan [updated 2023 Apr 7]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK541033/
Sari GAC, Purnomo HD, Sudijanto E. Penyakit perlemakan hati non-alkoholik pada sindroma metabolik dewasa: gambaran klinik dan hubungan antara jumlah komponen sindroma metabolik yang terganggu dengan derajat ultrasonografi. J Kedokt Diponegoro. 2012;1(1):373. Available from: https://www.neliti. com/publications/109095/penyakit-perlemakan-hati-non-alkoholik-pada-sindroma-metabolik-dewasa-gambaran-k
Kementerian Kesehatan RI. Survei Kesehatan Indonesia (SKI) 2023. [Internet] 2023; Available from: https://drive.google.com/file/d/1SAomJxUTXwlSzsRrGJfRPxzV3ZzypaRU/view
Nakagami H. Mechanisms underlying the bidirectional association between nonalcoholic fatty liver disease and hypertension. Hypertens Res. 2023;46(2):539–41. Doi:10.1038/s41440-022-01117-6.
Michopoulos S, Chouzouri VI, Manios ED, Grapsa E, Antoniou Z, Papadimitriou CA, et al. Untreated newly diagnosed essential hypertension is associated with nonalcoholic fatty liver disease in a population of a hypertensive center. Clin Exp Gastroenterol. 2016;9:1–9. Doi:10.2147/CEG.S92714.
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, et al. Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss. BMC Endocr Disord. 2022;22(1):1–9. Available from: https://doi.org/10.1186/s12902-022-00980-1
Anshori DM, Heru N, Sari G, Istiqomah H. Pemeriksaan Ultrasonografi Hepar menjadi Pemeriksaan Penunjang yang Tepat untuk Diagnosa Hepatitis. J Ilmu dan Teknol Kesehat. 2019;6(2):131–9. Doi:10.32668/jitek.v6i2.169.
Departemen Ilmu Penyakit Dalam FKUI. Buku Ajar Ilmu Penyakit Dalam Jilid 1 (6th ed). Jakarta: Interna Publishing; 2014.
Hadinata R, Loho E, Timban JFJ. Gambaran ultrasonografi hepar di bagian radiologi FK UNSRAT BLU RSUP Prof. Dr. R. D. Kandou Manado. e-CliniC. 2015;3(1):277–81. Available from: https://ejournal.unsrat.ac.id/v3/index.php/eclinic/article/view/6830
Marina D, Nugraha HG, Santiana L, Diyanti LN. Hubungan stadium hipertensi dengan derajat perlemakan menggunakan indeks hepatorenal sonografi. Glob Med Heal Commun. 2017;5(3):167. Available from: https://doi.org/10.29313/gmhc.v5i3.2175
Rengkung NP, Waleleng BJ, Palar S. Gambaran penyakit perlemakan hati non-alkoholik pada pasien hipertensi yang mempunyai SGPT meningkat. e-CliniC. 2015;3(1). Available from: https://ejournal.unsrat. ac.id/v3/index.php/eclinic/article/view/7657
Ng CH, Wong ZY, Chew NWS, Chan KE, Xiao J, Sayed N, et al. Hypertension is prevalent in non-alcoholic fatty liver disease and increases all-cause and cardiovascular mortality. Front Cardiovasc Med. 2022;9:942753. Doi:10.3389/fcvm.2022.942753.
Lonardo A, Nascimbeni F, Ballestri S, Fairweather DL, Win S, Than TA, et al. Sex differences in nonalcoholic fatty liver disease: state of the art and identification of research gaps. Hepatology. 2019;70(4):1457–69. Doi:10.1002/hep.30626.
Nagral A, Bangar M, Menezes S, Bhatia S, Butt N, Ghosh J, et al. Gender differences in nonalcoholic fatty liver disease. Euroasian J Hepatol. 2022;12(1):19–25. Doi:10.5005/jp-journals-10018-1370.
Kementerian Kesehatan RI. Laporan Nasional Riskesdas 2018 [Internet]. Lembaga Penerbit Balitbangkes. 2018. Available from: https://repository.badankebijakan.kemkes.go.id/id/eprint/3514/1/Laporan Riskesdas 2018 Nasional.pdf
Alqahtani SA, Schattenberg JM. NAFLD in the elderly. Clin Interv Aging. 2021;16:1633–49. Doi:10.2147/CIA.S295524.
Lin Y, Feng X, Cao X, Miao R, Sun Y, Li R, et al. Age patterns of nonalcoholic fatty liver disease incidence : heterogeneous associations with metabolic changes. Diabetol Metab Syndr. 2022;14:1–12. Available from: https://doi.org/10.1186/s13098-022-00930-w
Song Q, Ling Q, Fan L, Deng Y, Gao Q, Yang R, et al. Severity of non-alcoholic fatty liver disease is a risk factor for developing hypertension from prehypertension. Chin Med J (Engl). 2023;136(13):1591–7. Doi:10.1097/CM9.0000000000002111.
Ryoo JH, Suh YJ, Shin HC, Cho YK, Choi JM, Park SK. Clinical association between non-alcoholic fatty liver disease and the development of hypertension. J Gastroenterol Hepatol. 2014;29(11):1926–31. Doi:10.1111/jgh.12643.
Reza F, Mahatvavirya RW. Hubungan Derajat perlemakan hati non alkoholik menggunakan pemeriksaan indeks hepatorenal software image J Pada ultrasonografi dengan peningkatan kadar serum glutamik pyruvik transminase di RSUP Dr. Hasan Sadikin Bandung. Prim (Prima Med Journal). 2023;8(2):56–62. Doi:10.34012/pmj.v8i2.4253
Khoonsari M, Azar MMH, Ghavam R, Hatami K, Asobar M, Gholami A, et al. Clinical manifestations and diagnosis of nonalcoholic fatty liver disease. Iran J Pathol. 2017;12(2):99–105. Doi:10.30699/ijp.2017.25038
Petzold G. Role of ultrasound methods for the assessment of NAFLD. J Clin Med. 2022;11(15):4581. Doi:10.3390/jcm11154581
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Julio Gamis, Yovana P. M. Mamesah, Joan F. J. Timban

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
COPYRIGHT
Authors who publish with this journal agree to the following terms:
Authors hold their copyright and grant this journal the privilege of first publication, with the work simultaneously licensed under a Creative Commons Attribution License that permits others to impart the work with an acknowledgment of the work's origin and initial publication by this journal.
Authors can enter into separate or additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (for example, post it to an institutional repository or publish it in a book), with an acknowledgment of its underlying publication in this journal.
Authors are permitted and encouraged to post their work online (for example, in institutional repositories or on their website) as it can lead to productive exchanges, as well as earlier and greater citation of the published work (See The Effect of Open Access).