FORMULATION AND TEST OF ANTIOXIDANT ACTIVITY LOTION ETHYL ACETATE FRACTION OF CORN SILK (Zea mays L.)
Keywords:
Corn Silk, Lotion, Antioxidant, DPPH.Abstract
Corn Silk (Zea mays L.) is a plant that contains various active compounds such as flavonoids and fenols that function as antioxidants. This study aimed to test the effectivity of the antioxidant lotion ethyl acetate fraction of corn silk used the DPPH method and evaluated the physical preparations with physical properties test parameters. Corn silk was extracted using maceration method with 96% ethanol as solvent and fractionated with ethyl acetate as solvent.Lotion preparation were made into 5 formulas (F1-F5) with variations in the concentration of corn silk ethyl acetate fraction (2%-10%). The results showed that the lotion of the ethyl acetate fraction of corn silk had IC50 values respectively 128,96 ppm; 116,87 ppm; 102,96 ppm; 90,98 ppm; 64,68 ppm. F5 continued to evaluate the physical properties of the preparation. The results of the physical evaluation of the preparation showed that the lotion preparation filled the organoleptic requirements, homogeneity, pH, adhesion, spreadability. Based on the results of the study, it can be concluded that the lotion of the ethyl acetate fraction of corn silk has the effectivity as an antioxidant and fulfills the requirements for the parameters of the physical properties of the preparation.
References
Abdullah S. S, Djide N, Natsir S. 2021. KLT Bioautografi Hasil Partisi Ekstrak Etanol Herba Bandotan (Ageratum conyzoides L.) Terhadap Shigella dysentriae. Chem. Prog. 14(1) : 14-21.
Andayani., R, Maimunah, dan Y. Lisawati. 2008. Penentuan Aktivitas Antioksidan, Kadar Fenolat Total dan Likopen pada Buah Tomat (Solanum lycopersicum L). Jurnal Sains dan Teknologi Farmasi, Vol. 13, No. 1, 2008, halaman 31-37. ISSN : 1410 – 0177.
Cahya, Cucu Arum Dwi, dkk. 2019. Efektifitas Ekstrak Etanol Daun Sawi Hijau (Brassica Rapa Var. Parachinensis) Sebagai Pelembab Kulit Dengan Sediaan Masker Peel-Off. Jurnal Farmasi 2(1) : 6-15.
Febrianti, Petrina., Prabowo, Cahyo, Wisnu., Rijai, Laode. 2017. Aktivitas Antioksidan Dan Tabir Surya Ekstrak Daun Afrika (Vernonia amygdalina Del). Skripsi. Fakultas Farmasi Universitas Mulawarman, Samarinda. 23-24.
Garg, A., Aggarwal, D., Garg, S., Sigla, A.K. 2002. Spreading of Semisolid Formulation: An Update. Pharmaceutical Technology. 84-102.
Hartanto dkk, 2018. Kualitas dan Aktivitas Antioksidan Seduhan Teh Rambut Jagung (Zea mays) dengan Variasi Lama Pelayuan dan Usia Panen. Biota. 3 (1): 12−23.
Hassan, S.H.A., Fry, J.R. and Bakar, M.F.A., 2013. Antioxidant and phytochemical study on pengolaban (Litsea garciae), an edible underutilized fruit endemic to Borneo. Food Science and Biotechnology, 22(5), pp.1-7.
Kantor, M. N. N. 2015. Aktivitas Antibakteri Ekstrak Karang Lunak Xenia sp.yang Diperoleh dari Teluk Manado [Skripsi]. Fakultas Matematika dan Ilmu Pengetahuan Alam, Manado.
Kedare, S.B. and Singh, R.P., 2011. Genesis and development of DPPH method of antioxidant assay. Journal of food science and technology, 48(4). 412-422.
Kusriani, Herni dkk,. 2017. Aktivitas Antioksidan dan Tabir Surya dari Tongkol dan Rambut Jagung (Zea mays L.) IJPST. 4(1).
Molyneux, P. 2004. The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity. Songklanakarin Journal of Science Technology. 26(2), 211-219.
Noer, Benjamin M dan Sundari. 2016. Formulasi Hand and Body Lotion Ekstrak Kulit Buah Naga Putih (Hylocereus undatus) dan Uji Kestabilan Fisiknya. JPP (Jurnal Poltekkes Palembang), 11 (1).
Yamlean, P,, V., Y. 2016. Aktivitas Antibakteri Salep Ekstrak Dan Kembang Sepatu (Hibiscus Rosa Sinensis L.) Terhadap Luka Yang Terinfeksi Bakteri Staphylococcus Aureus Pada Kelinci (Oryctolagus cuniculus). Jurnal Pharmacon. 5(4).
Yamlean, P,, V., Y. 2017. Formulasi Dan Uji Antibakteri Sediaan Sabun Cair Ekstrak Daun Kemangi (Ocymum basilicum L.) Terhadap Bakteri Staphylococcus Aureus. Journal Pharmacon. 6(1).
Yamlean, P,, V., Y. Edwin, D., Q. & Widdhi, B. 2019. Variasi Basis Salep Minyak Kemiri (Aleurites moluccana) Dan Uji Daya Penyembuhannya Pada Luka Kelinci. Jurnal Ilmu Kefarmasian Indonesia. 17(2): 232-237.
Pogaga, E., dan P. V. Y. Yamlean dan J. S. Lebang. 2020. Formulasi dan Uji Aktivitas Krim Ekstrak Etanol Daun Murbei (Morus alba L.) Menggunakan Metode DPPH. Pharmacon. 9(3): 349-356.
Pujiastuti, Anasthasia dan Monica Kristiani. 2019. Formulasi dan Uji Stabilitas Mekanik Hand and Body Lotion Sari Buah Tomat (Licopersicon esculentum Mill.) sebagai Antioksidan. Jurnal Farmasi Indonesia, 16 (1).
Purwaningsih S, Salamah E. 2014. Formulasi Skin Lotion dengan Penambahan Karagenan dan Antioksidan Alami dari Rhizophora mucronata Lamk. J Akuatika V.; V(1).
Sayuti, K. & Yenrina, R., 2015. Antioksidan Alami dan Sintetik, Cetakan I. Padang : Jurnal Andalas University Press.
SNI. 1996. SNI. 16-4399-1996. Sediaan Tabir Surya. Jakarta: Dewan Standarisasi Nasional.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 PHARMACON
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
