AKTIVITAS ANTIKANKER SERVIKS RUMPUT LAUT Sargassum sp
DOI:
https://doi.org/10.35800/mthp.9.2.2021.31690Keywords:
Kata Kunci, Sargassum sp, kanker serviks, HPV, sel HeLa, obat anti kanker.Abstract
Kanker merupakan kondisi patologis yang menjadi salah satu utama penyebab kematian didunia. Selama beberapa dekade terakhir, langkah luar biasa telah dibuat untuk mengurangi insiden dan kematian kanker serviks dengan penerapan berbagai strategi pencegahan dan pengobatan. Tujuan penulisan artikel ilmiah untuk menemukan senyawa antikanker baru, yang sangat penting untuk pengobatan kanker dari rumput laut, karena rumput laut adalah salah satu produk laut sumber terbesar metabolit kimia aktif. Penelusuran literature menggunakan kata kunci, Sargassum sp, kanker serviks, HPV, obat antikanker serviks. Metode pengumpulan literature mengunakan elelectronic data base: PubMed, Web of Science, Science Direct, Elsevier, Springer Google and Google Scholar. Hasil yang diperoleh:, mekanisme senyawa antikanker melawan virus, aktifitas sitotoksik rumput laut melawan sel HeLa dan bebetapa jenis obat antikanker. Dapat disimpulkan bahwa Sargassum sp. mempunyai aktifitas sitotoksik melawan sel HeLa, sehingga dapat dijadikan sumber obat antikanker serviks. Rumput laut Sargassum sp. yang tumbuh melimpah di Indonesia dapat digunakan didalam pengobatan untuk menurunkan tingkat kasus dan kematian akibat kanker.
References
Ajdari, Z., Rahman, H., Shameli, K., Abdullah, R., Abd Ghani, M. A., Swee Yeap, S., Abbasiliasi, S., Ajdari, D., & Ariff, A. (2016). Novel Gold Nanoparticles Reduced by Sargassum glaucescens: Preparation, Characterization and Anticancer Activity. Molecule, 21(123): 1-17.
Akbari, V., Zafari, S., Yegdaneh, A. (2018). Anti-tuberculosis and cytotoxic evaluation of the seaweed Sargassum boveanum. 13(1): 30-37.
Alvest C., Silva J., Pinteus S., Gaspar H., Alpoim M.C., Botana L.M., Pedrosa R. 2018. From marine origin to therapeutics: The antitumor potential of marine algae-derived compounds. Front. Pharmacol. 9:777.
Arsianti, A., Bahtiar, A., Wangsaputra, V.K., Azizah N.N., Fachri, W., Nadapdap, L.D., Ajeng Megawati Fajrin A.M., Tanimoto H., Kakiuchi K. 2020. Phytochemical Composition and Evaluation of Marine Algal Sargassum polycystum for Antioxidant Activity and In Vitro Cytotoxicity on Hela Cells. Pharmacogn J. 12(1):88-94.
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians 69(6): 394-424.
Burk, R. D., Chen, Z., Saller, C., Tarvin, K., Carvalho, A. L., Scapulatempo-Neto, C., et al. (2017). Integrated genomic and molecular characterization of cervical cancer. Nature 543, 378–384.
Cong O, Du Z, Liao W, Zhang L, Yao Y, Ding K (2016). Sulfated fucoidan FP08S2 inhibits lung cancer cell growth in vivo by disrupting angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/ VEGF signaling. Cancer Lett 382:44–52 68.
Criscitiello, C.; Esposito, A.; Curigliano, G. (2014) Tumor-stroma crosstalk: Targeting stroma in breast cancer. Curr. Opin. Oncol, 26, 551–555.
Deepika, M. S., Thangam, R., Sheena, T. S., Sasirekha, R., Sivasubramanian, S., Babu, M. D., Thirumurugan, R. (2019). A novel rutin-fucoidan complex based phytotherapy for cervical cancer through achieving enhanced bioavailability and cancer cell apoptosis. Biomedicine & Pharmacotherapy, 109, 1181–1195. doi:10.1016/j.biopha.2018.10.178.
Dianti, N., R. & Isfandiari M. A. (2016) Cervical cancer risk difference based on personal Hygiene among childbearing age women at yayasan kanker Wisnuwardhana Surabaya. Jurnal Promkes, 4(1): 82–91.
Ercolano G., De Cicco P. and Ianaro A. 2019. New Drugs from the Sea: Pro-Apoptotic Activity of Sponges and Algae Derived Compounds. Marine Drug. 1-31.
Firdaus, M., Setijawati, D., Islam, I., Nursyam, H., Kartikaningsih, H., Yufidasari, H. S., Jaziri, A. A. (2018). The reducibility of heLa cell viability by Sargassum polycystum extracts. IOP Conference Series: Earth and Environmental Science, 137, 012064. doi:10.1088/1755-1315/137/1/012064
Gambato, G., Baroni, É., Garcia, C., Frassini, R., Frozza, C., Moura, S., Pereira, C., Fujii, M., Colepicolo, P., Lambert, A., Henriques,J. and Roesch-Ely, M. (2014) Brown Algae Himantothallus grandifolius (Desmarestiales, Phaeophyceae) Suppresses Proliferation and Promotes Apoptosis-Mediated Cell Death in Tumor Cells. Advances in Biological Chemistry, 4, 98-108.
Gomes, D., Telles, C., Costa, M., Almeida-Lima, J., Costa, L., Keesen, T., & Rocha, H. (2015). Methanolic Extracts from Brown Seaweeds Dictyota cilliolata and Dictyota menstrualis Induce Apoptosis in Human Cervical Adenocarcinoma HeLa Cells. Molecules, 20(4), 6573–6591.
Gross, S.; Rahal, R.; Stransky, N.; Lengauer, C.; Hoeflich, K.P. Targeting cancer with kinase inhibitors.J. Clin. Investig. 2015, 125, 1780–1789.
Hsu H.Y. and H.wang P.A. 2019. Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy. Clin. Translanslatiom. Medicine. 8:15
Hsu, HY., Lin, TY., Lu, MK., Leng PJ., Tsao, SM., Wu, YC. (2017). Fucoidan induces Toll-like receptor 4-regulated reactive oxygen species and promotes endoplasmic reticulum stress-mediated apoptosis in lung cancer. Sci Rep 23(7):44990.
Kashyap, N., Krishnan, N., Kaur, S., & Ghai, S. (2019). Risk Factors of Cervical Cancer: A Case-Control Study. Asia-Pacific Journal of Oncology Nursing, 6(3), 308-31.
KKP. (2017). Kementrian Kelautan dan Perikanan. Memajukan akuakultur diIndonesia.
Majunder, I., Subhabrata, P., Rita, K. (2015). Anti-Cancerous And-Tumorous Avtivity Of Algae-A Review 3(2):72-89
Pal and Kundu R. (2019). Human Papillomavirus E6 and E7: The Cervical Cancer Hallmarks and Targets for Terapy. Frountiers in Microbiology, 10(3116): 1-15.
Ruiz-Torres, V., Encinar, J. A., Herranz-Lopez, M., Perez-Sanchez, A., Galiano, V., Barrajon-Catalan, E., Micol, V. (2017). An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs. Molecules, 22(7): 1037.
Rushdi, M. I., Iman, A. M., Abdel-Rahman, Saber, H., Attia, E. Z., Wedad, M., Abdelraheem, Hashem, A., Madkour, Hossam, M., Hassan, H. M., Abeer H., Elmaidomy A. H., and Abdelmohsen, U. R. (2020). Pharmacological and natural products diversity of the brown algae genus Sargassum. Royal Society of Chemistry Advance, 10: 24951–24972.
Serrano, B., Brotons, M., Bosch, F. X., and Bruni, L. (2017). Epidemiology and burden of HPV related disease. Best Pract. Res. Clin. Obstet. Gynaecol. 47, 14–26.
Shilpha, J., Satish, L., & Ramesh, M. (2017). Recent Advancements in the Clinical Evaluation of Plant-Derived Anticancer Compounds. Anticancer Plants: Clinical Trials and Nanotechnology, 233–252.
Su, Z.; Yang, Z.; Xu, Y.; Chen, Y.; Yu, Q. Apoptosis, autophagy, necroptosis, and cancer metastasis. Mol. Cancer 2015, 14, 48.
Sun, Y., Hou, S., Song, S., Zhang, B., Ai, C., Chen, X., Liu, N. 2018. Impact of acidic, water and alkaline extraction on structural features, antioxidant activities of Laminaria japonica polysaccharides. Int. J. Biol. Macromol, 112:985–995.
Vaseghi, G., Sharifi, M., Dana, N.,Ghasemi, A., and Yegdaneh, A. (2018). Cytotoxicity of Sargassum angustifolium Partitions against Breast and Cervical Cancer Cell Lines. Advanced Biomedical Research. 7(43)
Yoshimoto, M., Higaki, K., Nanba, E., Ikequchi, M. (2015) Anti-proliferation activity of fucoidan in MKN45 gastric cancer cells and down regulation of phosphorylated ASK1, a cell cycle-regulated kinase. Yonago Acta Medica 58:1–7.
Zailanie, K., Hartatik, K. H., and Umi, K. U. (2015). Effect of Sargassum filipendula Fucoxanthin against HeLa Cell and Lymphocyte Proliferation Journal Life Science and Biomedicine. 5(2): 53-59.
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