Novel Innovations in Herbal Wine and Pharmacological Potential
DOI:
https://doi.org/10.35799/jbl.v15i1.62572Keywords:
Bioactive compounds, Herbal, Pharmacological, Saccharomyces cerevisae, WineAbstract
In recent years, the wine industry has undertaken various innovations to support the development of functional foods, as evidenced by numerous wine products formulated with herbal plants. These combinations have resulted in a diversity of secondary metabolites, which are of significant interest to the pharmaceutical industry. Nevertheless, further breakthroughs are needed to introduce novelty in herbal wine products. One such innovation involves the utilization of Cymbopogon citratus, Zingiber officinale, Citrus hystrix, Elettaria cardamomum, Cinnamomum verum, Syzygium aromaticum, and Caesalpinia sappan L. This study identified 85 compounds, demonstrating distinct differences in the chemical of bioactive compounds between the raw herbal plants and the fermented product. These differences are attributed to substitution reactions occurring in the carbon framework, resulting in the formation of derivative compounds in the herbal wine. Additionally, enzymatic reactions mediated by Saccharomyces cerevisiae during fermentation led to the formation of biologically important precursors, such as N-Acetylmannosamine, which plays a role in the regulation of GNE gene mutations. Therefore, the herbal wine produced in this study presents potential as a functional food with promising pharmacological applications.
References
Abdelli, A., Azzouni, S., Plais, R., Gaucher, A., Efrit, M. L., & Prim, D. (2021). Recent advances in the chemistry of 1,2,4-triazoles: Synthesis, reactivity and biological activities. Tetrahedron Letters, 86, 153518. https://doi.org/10.1016/j.tetlet.2021.153518
Adnan, Md., Jeon, B.-B., Chowdhury, Md. H. U., Oh, K.-K., Das, T., Chy, Md. N. U., & Cho, D.-H. (2022). Network Pharmacology Study to Reveal the Potentiality of a Methanol Extract of Caesalpinia sappan L. Wood against Type-2 Diabetes Mellitus. Life, 12(2), 277. https://doi.org/10.3390/life12020277
Aggarwal, R., & Sumran, G. (2020). An insight on medicinal attributes of 1,2,4-triazoles. European Journal of Medicinal Chemistry, 205, 112652. https://doi.org/10.1016/j.ejmech.2020.112652
Benmakhlouf, Z., Benserradj, O., & Kellab, R. (2022). Short Communication: Identification of phytochemical constituents of Syzygium aromaticum L. using gas chromatography coupled with mass spectrometry and evaluation of antimicrobial activity. Biodiversitas Journal of Biological Diversity, 23(5), 2586–2593. https://doi.org/10.13057/biodiv/d230540
Bhise, P., & Morya, S. (2021). The health sustainability of herbal wine bioactives towards different chronic diseases. The Pharma Innovation, 6(7), 512–517. https://doi.org/10.22271/tpi.2021.v10.i5g.6258
Carrillo, N., Malicdan, M. C., Leoyklang, P., Shrader, J. A., Joe, G., Slota, C., Perreault, J., Heiss, J. D., Class, B., Liu, C.-Y., Bradley, K., Jodarski, C., Ciccone, C., Driscoll, C., Parks, R., Van Wart, S., Bayman, L., Coffey, C. S., Quintana, M., … Gahl, W. A. (2021). Safety and efficacy of N-acetylmannosamine (ManNAc) in patients with GNE myopathy: an open-label phase 2 study. Genetics in Medicine, 23(11), 2067–2075. https://doi.org/10.1038/s41436-021-01259-x
Castillo, N. E. T., Teresa-Martínez, G. D., Alonzo-Macías, M., Téllez-Pérez, C., Rodríguez-Rodríguez, J., Sosa-Hernández, J. E., Parra-Saldívar, R., Melchor-Martínez, E. M., & Cardador-Martínez, A. (2023). Antioxidant Activity and GC-MS Profile of Cardamom (Elettaria cardamomum) Essential Oil Obtained by a Combined Extraction Method—Instant Controlled Pressure Drop Technology Coupled with Sonication. Molecules, 28(3), 1093. https://doi.org/10.3390/molecules28031093
Chawafambira, A. (2021). The effect of incorporating herbal (Lippia javanica) infusion on the phenolic, physicochemical, and sensorial properties of fruit wine. Food Science & Nutrition, 9(8), 4539–4549. https://doi.org/10.1002/fsn3.2432
Combt, D. G., & Roseman, S. (1960). The Sialic Acids I.The Structure and Enzymatic Synthesis of N-Acetylneuraminic Acid. The Journal Of Biological Chemistry, 235(9).
Creveling, C. R., McNeal, E. T., Cantacuzene, D., & Kirk, K. L. (1981). Influence of Fluorine Substitution on the Site of Enzymatic O-Methilation of Fluorinated Norephinephrines. Journal of Medicinal Chemistry, 24(12), 1399–1403.
El-Saber Batiha, G., Alkazmi, L. M., Wasef, L. G., Beshbishy, A. M., Nadwa, E. H., & Rashwan, E. K. (2020). Syzygium aromaticum L. (Myrtaceae): Traditional Uses, Bioactive Chemical Constituents, Pharmacological and Toxicological Activities. Biomolecules, 10(2), 202. https://doi.org/10.3390/biom10020202
Estiasih, T., Maligan, J. M., Witoyo, J. E., Mu’alim, A. A. H., Ahmadi, K., Mahatmanto, T., & Zubaidah, E. (2025). Indonesian traditional herbal drinks: diversity, processing, and health benefits. Journal of Ethnic Foods, 12(1), 7. https://doi.org/10.1186/s42779-025-00267-5
Kumaresan, S. M., Sathasivam, R., Somanathan, H., Sivaram, S., Christopher, D., Anbalagan, A., Muthuraman, M. S., & Park, S. U. (2024). Production, antimicrobial, antioxidant, sensory, and therapeutic properties of herbal wine – A comprehensive review. Journal of Applied Botany and Food Quality, 97(1–14), 1–14. https://doi.org/10.5073/JABFQ.2024.097.001
Lee, H. S., & Choi, C.-I. (2023). Black Goji Berry (Lycium ruthenicum Murray): A Review of Its Pharmacological Activity. Nutrients, 15(19), 4181. https://doi.org/10.3390/nu15194181
Liu, J., Guan, W., Sun, Z., Ni, Y., He, L., Tian, F., & Cai, L. (2024). Application of Cyclocarya paliurus–Kiwifruit Composite Fermented to Enhance Antioxidant Capacity, Flavor, and Sensory Characteristics of Kiwi Wine. Molecules, 29(1), 32. https://doi.org/10.3390/molecules29010032
Lu, L., Mi, J., Chen, X., Luo, Q., Li, X., He, J., Zhao, R., Jin, B., Yan, Y., & Cao, Y. (2022). Analysis on volatile components of co-fermented fruit wines by Lycium ruthenicum murray and wine grapes. Food Science and Technology, 42. https://doi.org/10.1590/fst.12321
Martínez-Francés, V., Rivera, D., Obon, C., Alcaraz, F., & Ríos, S. (2021). Medicinal Plants in Traditional Herbal Wines and Liquors in the East of Spain and the Balearic Islands. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.713414
Morya, S., Menaa, F., Lourenço-Lopes, C., Jimenez-Lopez, C., Khalid, W., Moreno, A., Ikram, A., Khan, K. A., Ramniwas, S., & Mugabi, R. (2024). An Overview on Flavor Extraction, Antimicrobial and Antioxidant Significance, and Production of Herbal Wines. ACS Omega. https://doi.org/10.1021/acsomega.3c09887
Mullen, J., Alrasheed, K., & Mozaffar, T. (2022). GNE myopathy: History, etiology, and treatment trials. Frontiers in Neurology, 13. https://doi.org/10.3389/fneur.2022.1002310
Nguyen, A. N. H., Capone, D. L., Johnson, T. E., Jeffery, D. W., Danner, L., & Bastian, S. E. P. (2019). Volatile Composition and Sensory Profiles of a Shiraz Wine Product Made with Pre- and Post-Fermentation Additions of Ganoderma lucidum Extract. Foods, 8(11), 538. https://doi.org/10.3390/foods8110538
Nie, J.-Y., & Kirk, K. L. (1991). Synthesis of metabolites of 6-fluoro-DOPA. Journal of Flum-Kne Chemistry, 55, 259–269.
Perestrelo, R., Silva, C., Silva, P., & Câmara, J. (2018). Establishment of the Volatile Signature of Wine-Based Aromatic Vinegars Subjected to Maceration. Molecules, 23(2), 499. https://doi.org/10.3390/molecules23020499
Schaller, T., & Schieberle, P. (2020). Comparison of the Key Aroma Compounds in Fresh, Raw Ginger (Zingiber officinale Roscoe) from China and Roasted Ginger by Application of Aroma Extract Dilution Analysis. Journal of Agricultural and Food Chemistry, 68(51), 15292–15300. https://doi.org/10.1021/acs.jafc.0c06731
Snopek, L., Mlcek, J., Sochorova, L., Baron, M., Hlavacova, I., Jurikova, T., Kizek, R., Sedlackova, E., & Sochor, J. (2018). Contribution of Red Wine Consumption to Human Health Protection. Molecules, 23(7), 1684. https://doi.org/10.3390/molecules23071684
Soni, S. K., Swami, U., Trivedi, N., & Soni, R. (2021). Wine as a Complete Functional Beverage : A Perspective. In V. K. Joshi & R. C. Ray (Eds.), Winemaking Basics and Applied Aspects (p. 67). CRC Press, Taylor & Francis Group.
Strzelecka, M., & Świątek, P. (2021). 1,2,4-Triazoles as Important Antibacterial Agents. Pharmaceuticals, 14(3), 224. https://doi.org/10.3390/ph14030224
Sujarwo, W., Keim, A. P., Savo, V., Guarrera, P. M., & Caneva, G. (2015). Ethnobotanical study of Loloh: Traditional herbal drinks from Bali (Indonesia). Journal of Ethnopharmacology, 169, 34–48. https://doi.org/10.1016/j.jep.2015.03.079
Van Wart, S., Mager, D. E., Bednasz, C. J., Huizing, M., & Carrillo, N. (2021). Population Pharmacokinetic Model of N-acetylmannosamine (ManNAc) and N-acetylneuraminic acid (Neu5Ac) in Subjects with GNE Myopathy. Drugs in R&D, 21(2), 189–202. https://doi.org/10.1007/s40268-021-00343-6
Zhao, X., Wang, Z., Tang, F., Cai, W., Peng, B., & Shan, C. (2024). Exploring jujube wine flavor and fermentation mechanisms by HS-SPME-GC–MS and UHPLC-MS metabolomics. Food Chemistry: X, 21, 101115. https://doi.org/10.1016/j.fochx.2024.101115
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Dwi Rahayu Pujiastuti, Mario Nikolaus Dalengkade
This work is licensed under a Creative Commons Attribution 4.0 International License.
