Aktivitas Antikanker Serviks Rumput Laut Gracilaria sp.
DOI:
https://doi.org/10.35800/mthp.9.3.2021.31692Keywords:
Kata Kunci, Gracilaria sp, kanker serviks, HPV, sel Hela obat anti kanker.Abstract
Kanker serviks merupakan penyakit kanker urutan ketiga terbesar didunia. Beberapa dekade terakhir, metode pengobatan kanker yang sudah digunakan dalam dunia pengobatan yakni tindakan operasi, radiasi, dan kemoterapi. Sebanyak sepertiga penderita kanker diperkirakan dapat disembuhkan dengan tindakan bedah dan radiasi, namunnya bagi dua pertiga lainnya terutama pada penyakit kanker yang telah menyerang ke organ lain, diperlukan modalitas terapi yang bersifat sistemik yaitu kemoterapi. Tujuan penulisan artikel ilmiah ini untuk menemukan senyawa antikanker baru, yang sangat penting untuk pengobatan kanker dari rumput laut, karena rumput laut adalah salah satu produk laut sumber terbesar metabolit kimia aktif. Penelusuran literature menggunakan kata kunci, Gracilaria sp, kanker serviks, HPV, obat antikanker serviks. Metode pengumpulan literature mengunakan elelectronic data base: PubMed, Web of Science, Science Direct, and Google Scholar. Hasil yang diperoleh: Dapat disimpulkan bahwa Gracilaria sp. yang mempunyai aktifitas sitotoksik melawan sel Hela sebesar IC50 13,8 – 71,4% (µg/ml), sehingga dapat dijadikan sumber obat antikanker serviks. Rumput laut Gracilaria sp. yang tumbuh melimpah di Indonesia dapat digunakan didalam pengobatan untuk menurunkan tingkat kasus dan kematian akibat kanker.
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